Synthesis and characterization of poly(N-isopropylmethacrylamide-co-N-isopropylacrylamide) copolymers
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Copolymeric hydrogels based on poly(N-isopropylmethacrylamide-co-N-isopropylacrylamide), p(NIPMAM/NIPAM), are synthesized by radical polymerization of N-isopropylmethacrylamide (NIPMAM) and N-isopropylacrylamide (NIPAM) monomers in ratio 40/60 mol% with 1.5, 2 and 3 moles of cross-linker ethylen glycol dimethacrylate (EGDM) per 100 moles of monomers. The polymerization reactions were initiated with 30 mg 2,2-azobis(2-methylpropionitrile), AIBN. The synthesized copolymeric p(NIPMAM/NIPAM) hydrogels, starting monomers and the cross-linker were structurally characterized by using Fourier transform infrared spectroscopy (FTIR). In order to determine residual reactants, synthesized hydrogels were treated with methanol and analyzed by high-pressure liquid chromatography (HPLC). Swelling of p(NIPMAM/NIPAM) hydrogels was investigated in relation to the temperature (25, 37, 60 and 80 °C), pH value of the solution (4, 7 and 8) and cross-linker content. The obtained values of residual monomer quantities are within acceptable limits and range from 2.69 to 5.25 mg/g for NIPMAM and 14.55 to 30.80 mg/g for NIPAM. The synthesized p(NIPMAM/NIPAM) hydrogels are negative temperature sensitive. The most common mechanisms of transport solution for p(NIPMAM/NIPAM) hydrogels are polymer chain relaxation, (Case III), and anomalous type of diffusion (non-Fickian diffusion). The maximum equilibrium degree of swelling was reached by p(NIPMAM/NIPAM) hydrogel with 1.5 mol% of EGDM at a temperature of 25 °C and pH 4 (ae=51.19), whereas the minimum one was reached by p(NIPMAM/NIPAM) hydrogel with 3 mol% of EGDM at a temperature of 80 °C and pH 7 (ae=0.98).
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