Transport of silver nanoparticles from nanocomposite Ag/alginate hydrogels under conditions mimicking tissue implantation
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The aim of this work was to assess phenomena occurring during AgNP transport from nanocomposite Ag/alginate hydrogels under conditions relevant for potential biomedical applications as antimicrobial soft tissue implants. First, we have studied AgNP migration from the nanocomposite to the adjacent alginate hydrogel mimicking soft tissue next to the implant. AgNP deposition was carried out by the initial burst release lasting for ~24 h yielding large aggregates on hydrogel surfaces and smaller clusters (~400 nm in size) inside. However, the overall released content was low (0.67%) indicating high nanocomposite stability. In the next experimental series, release of AgNPs, 10–30 nm in size, from Ag/alginate microbeads in water was investigated under static conditions as well as under continuous perfusion mimicking vascularized tissues. Mathematical modeling has revealed AgNP release by diffusion under static conditions with the diffusion coefficient within the Ag/alginate hydrogel of 6.9´10–19 m2 s–1. Conversely, continuous perfusion induced increased AgNP release by convection with the interstitial fluid velocity estimated as 4.6 nm s–1. Overall, the obtained results indicated the influence of hydrodynamic conditions at the implantation site on silver release and potential implant functionality, which should be investigated at the experimentation beginning using appropriate in vitro systems.
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X.-F. Zhang, Z.-G. Liu, W. Shen, S. Gurunathan, Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches, Int. J. Mol. Sci. 17 (2016) 1534–1568.
H. Palza, Antimicrobial polymers with metal nanoparticles, Int. J. Mol. Sci. 16 (2015) 2099–2116.
J. Natsuki, T. Natsuki, Y. Hashimoto, A review of silver nanoparticles: synthesis methods, properties and applications, Int. J. Mater. Sci. Appl. 4 (2015) 325–332.
H. McVeigh, Topical silver for preventing wound infection, Int. J. Evid. Based. Healthc. 9 (2011) 454–455.
B.S. Atiyeh, M. Costagliola, S.N. Hayek, S. Dibo, Effect of silver on burn wound infection control and healing: Review of the literature, Burns 33 (2007) 139–148.
J. Stojkovska, Ž. Jovanović, I. Jančić, B. Bufan, M. Milen-ković, V. Mišković-Stanković, B Obradović, Novel Ag/alginate nanocomposites for wound treatments: animal studies, Rane 4 (2013) 17–22.
Y. Liu, Z. Zheng, J.N. Zara, C. Hsu, D.E. Soofer, K.S. Lee , R.K. Siu , L.S. Miller, X. Zhang, D. Carpenter, C. Wang, K. Ting, C. Soo, The antimicrobial and osteoinductive properties of silver nanoparticle/poly (DL-lactic-co-glycolic acid)-coated stainless steel, Biomaterials 33 (2012) 8745–8756.
W. Paul, C. Sharma, Chitosan and alginate wound dressings: a short review, Trends Biomater. Artif. Organs. 18 (2004) 18–23.
K.Y. Lee, D.J. Mooney, Alginate: Properties and biomedical applications, Prog. Polym. Sci. 37 (2012) 106–126.
E.A. Growney Kalaf, R. Flores, J.G. Bledsoe, S.A. Sell, Characterization of slow-gelling alginate hydrogels for intervertebral disc tissue-engineering applications, Mater. Sci. Eng. C 63 (2016) 198–210.
J. Stojkovska, B. Bugarski, B. Obradovic, Evaluation of alginate hydrogels under in vivo-like bioreactor conditions for cartilage tissue engineering, J. Mater. Sci. Mater. Med. 21 (2010) 2869–2879.
C.C. Wang, K.C. Yang, K.H. Lin, Y.L. Liu, H.C. Liu, F.H. Lin, Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold, Biomaterials 33 (2012) 120–127.
Ž. Jovanović, J. Stojkovska, B. Obradović, V. Miskovic-Stankovic, Alginate hydrogel microbeads incorporated with Ag nanoparticles obtained by electrochemical method, Mater. Chem. Phys. 133 (2012) 182–189.
B. Obradovic, V. Mišković-Stanković, Ž. Jovanović, J. Stojkovska, 2015. Production of alginate microbeads with incorporated silver nanoparticles. patent RS53508 B1.
M.C. Stensberg, Q. Wei, E.S. McLamore, D.M. Porterfield, A. Wei, M.S. Sepúlveda, Toxicological studies on silver nanoparticles: challenges and opportunities in assessment, monitoring and imaging, Nanomedicine (Lond). 6 (2011) 879–898.
A.T. Florence, "Targeting" nanoparticles: The constraints of physical laws and physical barriers, J. Control. Release 164 (2012) 115–124.
T.-Y. Lee, M.-S. Liu, L.-J. Huang, S.-I. Lue, L.-C. Lin, A.-L. Kwan, R.-C. Yang, Bioenergetic failure correlates with autophagy and apoptosis in rat liver following silver nanoparticle intraperitoneal administration, Part. Fibre Toxicol. 10 (2013) 40.
B. Katsnelson, L.I. Privalova, V.B. Gurvich, O.H. Makeyev, V.Y. Shur, Y.B. Beikin, M.P. Sutunkova, E.P. Kireyeva, I. Minigalieva, N.V. Loginova, M.S. Vasilyeva, A.V. Korotkov, E. Shuman, L. Vlasova, E.V. Shishkina, A.E. Tyur-nina, R.V. Kozin, I.E. Valamina, S.V. Pichugova, L.G. Tulakina, Comparative in vivo assessment of some adverse bioeffects of equidimensional gold and silver nanoparticles and the attenuation of nanosilvers effects with a complex of innocuous bioprotectors, Int. J. Mol. Sci. 14 (2013) 2449–2483.
H.J. Johnston, G. Hutchison, F.M. Christensen, S. Peters, S. Hankin V. Stone, A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity, Crit. Rev. Toxicol. 40 (2010) 328–346.
C. Rigo, L. Ferroni, I. Tocco, M. Roman, I. Munivrana, C. Gardin, W.R.L. Cairns, V. Vindigni, B. Azzena, C. Barbante, B.Zavan, Active silver nanoparticles for wound healing, Int. J. Mol. Sci. 14 (2013) 4817–4840.
G. Doig, G.H. Yeoh, V. Timchenko, G. Rosengarten, T.J. Barber, S.C.P. Cheung, Simulation of blood flow and nanoparticle transport in a stenosed carotid bifurcation and pseudoarteriole, J. Comput. Multiph. Flows 4 (2012) 85–102.
A. Lankoff, W.J. Sandberg, A. Wegierek-Ciuk, H. Lisowska, M. Refsnes, B. Sartowska, P.E. Schwarze, S. Meczynska-Wielgosz, M. Wojewodzka, M. Kruszewski, The effect of agglomeration state of silver and titanium dioxide nanoparticles on cellular response of HepG2, A549 and THP-1 cells, Toxicol. Lett. 208 (2012) 197–213.
H. Al-Obaidi, A.T. Florence, Nanoparticle delivery and particle diffusion in confined and complex environments, J. Drug Deliv. Sci. Technol. 30 (2015) 266–277.
D. Kostic, S. Vidovic, B. Obradovic, Silver release from nanocomposite Ag/alginate hydrogels in the presence of chloride ions: experimental results and mathematical modeling, J. Nanoparticle Res. 18 (2016) 76–92.
T.I. Klokk, J.E. Melvik., Controlling the size of alginate gel beads by use of a high electrostatic potential, J. Microencapsul. 19 (2002) 415–424.
C. Rodríguez-Rivero, E.M.M. Del Valle, M.A. Galan, Experimental and linear analysis for the instability of non-Newtonian liquid jets issuing from a pressurized vibrating nozzle, AIChE J. 61 (2015) 2070–2078.
C. Schwinger, A. Klemenz, K. Busse, J. Kressler, Encapsulation of living cells with polymeric systems, Macromol. Symp. 210 (2004) 493–499.
U. Prusse, J. Dalluhn, J. Breford, K.-D. Vorlop, Production of spherical beads by JetCutting, Chem. Eng. Technol. 23 (2000) 1105–1110.
J. Stojkovska, D. Kostić, Ž. Jovanović, M. Vukašinović-Sekulić, V. Mišković-Stanković, B. Obradović, A comprehensive approach to in vitro functional evaluation of Ag/alginate nanocomposite hydrogels, Carbohydr. Polym. 111 (2014) 305–314.
N.M. Velings, M.M. Mestdagh, Physico-chemical properties of alginate gel beads, Polym. Gels Networks 3 (1995) 311–330.
E. Kon, G. Filardo, B. Di Matteo, F. Perdisa, M. Marcacci, Matrix assisted autologous chondrocyte transplantation for cartilage treatment: A systematic review, Bone Joint Res. 2 (2013) 18–25.
B. Bugarski, B. Obradovic, V.A. Nedovic, D. Poncelet, "Immobilization of cells and enzymes using electrostatic droplet generator", in Focus on Biotechnology, Volume 8a: Fundamentals of Cell Immobilisation Biotechnology, V. Nedovic, R.G. Willaert (Eds.), Kluwer Academic Publishers, Dordrecht, 2004, pp. 277–294.
D.E. Orr, K.J. Burg, Design of a modular bioreactor to incorporate both perfusion flow and hydrostatic compression for tissue engineering applications, Ann. Biomed. Eng. 36 (2008) 1228–1241.
B. Quah, C. Musante, J.C. White, X. Ma, Phytotoxicity, uptake, and accumulation of silver with different particle sizes and chemical forms, J. Nanoparticle Res. 17 (2015) 1–13.
M.I. González-Sánchez, S. Perni, G. Tommasi, N.G. Morris, K. Hawkins, E. López-Cabarcos, P. Prokopovich, Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications, Mater. Sci. Eng., C 50 (2015) 332–340.
Z. Jovanovic, A. Radosavljevic, Z. Kacarevic-Popovic, J. Stojkovska, A. Peric-Grujic, M. Ristic, I.Z. Matic, Z.D. Juranic, B. Obradovic, V. Miskovic-Stankovic, Bioreactor validation and biocompatibility of Ag/poly(N-vinyl-2-pyrrolidone) hydrogel nanocomposites, Colloids Surfaces, B 105 (2013) 230–235.
W.W. Stewart, H.E. Swaisgood, Characterization of calcium alginate pore diameter by size-exclusion chromatography using protein standards, Enzyme Microb. Technol. 15 (1993) 922–927.
G. Fundueanu, C. Nastruzzi, A. Carpov, J. Desbrieres, M. Rinaudo, Physico-chemical characterization of Ca-alginate microparticles produced with different methods, Biomaterials 20 (1999) 1427–1435.
J. Scallan, V.H. Huxley, R.J. Korthuis, Capillary Fluid Exchange: Regulation, Functions, and Pathology, Ch. 2, Morgan & Claypool Life Sciences, San Rafael, CA, 2010.
S.S. Dukhin, M.E. Labib, Convective diffusion of nano-particles from the epithelial barrier toward regional lymph nodes, Adv. Colloid Interface Sci. 199–200 (2013) 23–43.