Low moisture starch for improved viability and stability of new probiotic L. plantarum 299v preparation
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Probiotic pharmaceutical preparations are more and more popular because of the increasing level of evidence of their beneficial effect on human health. The goal of this study was to determine and develop the encapsulated probiotic formulation with the optimal filling amount of active ingredient - Lactobacillus plantarum that would, in combination with other active ingredients: iron, vitamin C and excipient starch, fulfil requirements for therapeutic action while maintaining process parameters requirements of manufacturing as well. The optimal formulation of a multicomponent probiotic-based formulation that fulfils requirements for sustaining all active ingredients while respecting technological process requirements, will enable a routine pharmaceutical manufacturing that could yield both efficient and safe dietary products.
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Reference
World Health Organization. Probiotics in food, Health and nutritional properties and guidelines for evaluation. Rome, Italy: FAO; 2001
Salminen S, Ouwehand AC, Isolauri E, Clinical Applications of Probiotic Bacteria, Int Dairy J 1998; 8: 563-572.
Saarela MH, Probiotic technology Maintaining viability and stability. Agro Food Industry Hi Tech 2007; 18: 19-21.
Alvarez MJ, Oberhelman RA, Probiotic Agents and Infectious Disease: A modern Perspective on a Traditional Therapy. Clin Infect Dis 2001; 32: 1567-1576.
Uddin MS, al Mamun A, M. Rashid, Asaduzzaaman M. In-process and Finished Products Quality Control Tests for Pharmaceutical Capsules According to Pharmacopoeias. British J Pharm Res 2015; 9: 1-9.
Dao H, Lakhani P, Police A, Kallakunta V, Ajjarapu SS, Wu K-W, Ponkshe P, Repka MA, Murthy SN, Microbial Stability of Pharmaceutical and Cosmetic Products. AAPS, Pharm SciTech 2018; 19: 60-78.
Narang AS, Boddu SHS. (Eds.), Excipient Application in Formulation Design and Drug Delivery. Springer International Publishing Switzerland 2015.
Vesterlund S, Salminen K, Salminen S. Water activity in dry foods containing live probiotic bacteria should be carefully considered: A case study with lactobacillus rhamnosus GG in flaxseed. Int J Food Microbiol. 2012; 157: 319-321.
Jimenez M, Andrade EF, Pascual-Pineda LA. Effect of water activity on the stability of Lactobacillus paracasei capsules. LWT Food Sci Tech 2015; 60: 346-351.
Albadran HA, Chatzitraghou A, Khutoryansky VV. Stability of probiotic Lactobacillus planatrum in dry microcapsules under accelerated storage conditions. Food Res Int 2015; 74: 208-216.
Hartesi B, Sriwidodo, Abdassah M, Chaerunisaa AY. Starch as Pharmaceutical Excipient. Int J Pharm Sci Rev Res 2016; 41: 59-64.
Brown J, Toppinig D. High amylose maize starch as a versatile prebiotic for use with probiotic bacteria. Food Australia 1998; 50: 603-610.
Pyar H, Peh KK. Entering coating of granules containing the probiotic Lact. Acidophilus. Acta Pharm 2014; 64: 247-256.
Sousa P, Sousa SC, Costa P. Development of Probiotic Tablets Using Micro particles: Viability Studies and Stability Studies. AAPS PharmSciTech 2013; 14: 121-127.
Hoppe H, Onning S, Berggren A, Hulten L. Probiotic strain Lactobacillus plantarum 299v increase iron absorption from an iron/supplemented fruit drink; a double-isotope cross-over single-blind study in women in reproductive age. British J Nutr 2015; 114: 1195-1202.
Khoshfetrat MR, Mortazavi S, Neyestani T, Mahmoodi MR, Zerafati-Shoae N, Mohammadi-Nasrabadi F. Iron and Vitamin C Co-Supplementation Increased Serum Vitamin C Without Adverse Effect on Zinc Level in Iron Deficient Female Youth. Int J Prevent Med 2014; 5: 1037-1044.
Biyani MK. Choosing Capsules: A Primer. Pharm Tech Eur 2017; 29: 24-27.
De Man JC., Rogosa M, Sharpe ME. A medium for the cultivation of lactobacill. J Appl Bacteriol 1960;23: 130-135.
CPMP/ICH/2736/99, ICH Q1A (R2): Stability testing of new drug substances and drug products. 2003.
Kaur M, Kaur G, Kaur H, Sharma S. Overview on stability studies. Int J Pharm Chem Biol Sci 2013; 3: 1231-1241.
European Directorate for the Quality of Medicines and Healthcare (EDQM). European Pharmacopoeia. 8.0. vol. 1. Strasbourg, France: EDQM; 2014.
Aiwaguore J, Ogunlowo OP, Agamah F. Comparative Study of the Physical Characteristics of Some Commercially Available Brands of Amoxicillin Capsules. Brit J Pharm Res 2015; 5: 359-369.
Stadler M, Viernstein H. Optimization of a formulation containing viable lactic acidbacteria. Int J Pharm 2003; 256: 117-122.