Sound based assembly of spatially organized porous constructs Abstract
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Abstract
An emerging contactless method for creating biologically relevant constructs is acoustic bioassembly. This method induces the assembly of particulate systems through fluid patterns (e.g., pressure fields, surface instabilities, waves). These fluid patterns produce hydrodynamic forces that are spatially specific and control the arrangement of micron-sized particles. The frequency and amplitude of the chamber vibrations directly regulate these forces. We decided to exploit this novel technique in combination with cell-laden gelatine beads. We then patterned the beads to generate spatially orchestrated porous constructs where cells can easily invade and proliferate.
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Guex, A. G., Di Marzio, N., Eglin, D., Alini, M., & Serra, T. (2021). The waves that make the pattern: a review on acoustic manipulation in biomedical research. Materials Today Bio, 10, 100110.
Neffe, A. T., Cruz, D. M. G., Roch, T., & Lendlein, A. (2021). Microparticles from glycidylmethacrylated gelatin as cell carriers prepared in an aqueous two-phase system. European Polymer Journal, 142, 110148.