Antibiotic production by Streptomyces hygroscopicus CH-7 in medium containing Schiff base complexes

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Published: Apr 29, 2019
DOI: https://doi.org/10.2298/HEMIND181016008I
Keywords:
antibiotic production, isatin-3-thiosemicarbazone, metal complexes morphology, Streptomyces hygroscopicus

Main Article Content

Slavica B Ilić
University of Niš, Faculty of Technology, Leskovac
Sandra S Konstantinović
University of Niš, Faculty of Technology, Leskovac
Gordana Dj Gojgić-Cvijović
Department of Chemistry, ICTM, University of Belgrade
Vlada B Veljković
University of Niš, Faculty of Technology, Leskovac

Abstract

Influence of a modified media on Hexaene H-85 and Azalomycine B production by Streptomyces hygroscopicus CH-7 was investigated. The amino acid L-tryptophan, as a nitrogen source, was replaced with isatin-3-thiosemicarbazone and its complexes with some divalent metal ions. Isatin-3-thiosemicarbazone was synthesized in crude glycerol obtained as a byproduct in biodiesel production from sunflower oil. The complexes were charac­terized by elemental microanalysis and magnetic susceptibility, as well as, by Atomic absorption(AA), Fourier-transform infrared (FTIR) and Ultraviolet–visible (UV/VIS) spectro­scopic methods. The spectral studies indicated an octahedral geometry for the Mn(II), Fe(II) and Ni(II) complexes and a tetrahedral one for the Zn(II) complex. Comparing to the basal medium, isatin-3-thiosemicarbazone (ITC) and its metal complexes in the concentration of 0.5 g dm-3 showed better results in the antibiotics production. Use of medium supple­mented with the Fe(II) complex resulted in the maximum Hexaene H-85 and Azalomycine B concentrations of 306 µg cm-3 and 127 µg cm-3,respectively. Addition of ITC and its complexes changed the morphology of S. hygroscopicus CH-7 from filaments to pellets as a dominant shape in media resulting in higher antibiotic production.

Article Details

How to Cite
[1]
S. B. Ilić, S. S. Konstantinović, G. D. Gojgić-Cvijović, and V. B. Veljković, “Antibiotic production by Streptomyces hygroscopicus CH-7 in medium containing Schiff base complexes”, Hem Ind, vol. 73, no. 2, pp. 93–101, Apr. 2019, doi: 10.2298/HEMIND181016008I.
Issue
Vol. 73 No. 2 (2019)
Section
Biochemical Engineering - General
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How to Cite

[1]
S. B. Ilić, S. S. Konstantinović, G. D. Gojgić-Cvijović, and V. B. Veljković, “Antibiotic production by Streptomyces hygroscopicus CH-7 in medium containing Schiff base complexes”, Hem Ind, vol. 73, no. 2, pp. 93–101, Apr. 2019, doi: 10.2298/HEMIND181016008I.
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