Sorpcija diklofenaka na selektivno oksidovanu celulozu
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Abstract
Vezivanje ljekovitih preparata na polimerne nosače određeno je vrstom nosača i strukturom samog lijeka. U ovom radu kao polimerni nosač korištena je selektivno oksidovana celuloza (OC) sa 0,547 i 1,163 mmol/g COOH. Dobijena je oksidacijom celuloznog zavoja smjesom HNO3-H3PO4-NaNO2 u trajanju od 5 i 10 časova na temperaturi 25±1 oC, i upotrebljena je za vezivanje analgetika diklofenak-kalijuma. Vezivanje lijeka vršeno je iz vodenog rastvora koncentracija c = 2,5∙10-3, 3,4∙10-3 i 5,1∙10-3 mol/L na temperaturi 26±1 oC, a desorpcija analgetika u fiziološkom rastvoru. Količine vezanog i otpuštenog lijeka određene su spektrofotometrijski na talasnoj dužini od λmax = 276 nm. Maksimalna količina vezanog lijeka nakon 24 h iznosila je 0,814 mmol/g OC (iz rastvora c = 5,1∙10-3 mol/L, na uzorku sa 1,163 mmol/g COOH), a maksimalna količina desorbovanog lijeka 0,063 mmol/g OC (nakon 24 h u fiziološkom rastvoru, uzorak sa 1,163 mmol/g COOH). U radu se proučava uticaj sadržaja COOH grupa i sorpcionih svojstava OC, kao i uticaj hemijske strukture diklofenaka, pH vrijednosti rastvora i trajanja sorpcije na količinu vezanog lijeka. Takođe, ispitana je i prekidna jačina oksidovanih celuloznih vlakana. Ustanovljeno je da se vezivanje lijeka ostvaruje pretežno vodoničnim vezama.
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