Stability of liposomal particles with encapsulated coumarin derivate Abstract
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Abstract
Coumarin derivates possess several biological effects, including anti-inflammatory, antioxidant, anticoagulant, antitumor, insecticidal, anthelminthic, hypnotic, antifungal, and HIV protease inhibition properties. Due to their solubility in organic solvents and insolubility in water and body fluids, their bioavailability is significantly low. Thus, they can be encapsulated into liposomal particles with the aim of overcoming the mentioned disadvantage. Hence, in the present study, coumarin derivate was encapsulated in phospholipid liposomes and their stability was monitored for 60 days in terms of vesicle size, polydispersity index (PDI), zeta potential, and mobility.
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