Activated charcoal as a carrier of probiotics: A new approach for pathogen elimination in wounds Abstract
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Abstract
Antibiotic resistance is one of the biggest threats to global health, food security and development today. However, development of conventional anti-infective drugs is going slowly, so new innovative strategies and more research are urgently needed in identifying, developing, implementing and evaluating novel therapies for antibiotic-resistant infections. The two-year ProHealingAC project, funded by the Science Fund of the Republic of Serbia, aims to use beneficial properties of AC and probiotic microorganisms in developing a new strategy for prevention and local treatment of antibiotic-resistant infections in wounds. Previously, it has been shown that activated charcoal (AC) in conjunction with different active agents has an efficient antimicrobial activity. The aim of this project is to develop biocomposites (BCs) based on AC fabric, as adsorptive component, and probiotics, as bioactive component in order to achieve their synergetic activity for efficient and sustained local delivery of bioactive agents directly into the wound area. Also, special attention has been given to the influence of glucose level (normo- and hyperglycemia) in the microenvironment of the wound.
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Funding data
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Science Fund of the Republic of Serbia
Grant numbers 9802
References
https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance
Osmokrovic A, Jancic I, Vunduk J, Petrovic P, Milenkovic M, Obradovic B. Achieving high antimicrobial activity: composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent. Carb Pol 2018; 196: 279-88. https://doi.org/10.1016/j.carbpol.2018.05.045
Osmokrovic A, Jancic I, Jankovic-Castvan I, Petrovic P, Obradovic B. Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings. Hem Ind 2019; 73 (1): 37-46.