Novel alginate/activated-charcoal platform for local treatment of resistant pathogens in wounds Abstract
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Abstract
Antibiotic resistance is one of the biggest threats to global health, food security, and development today and new strategies to address this clinical problem are urgently needed. The aim of this work was to produce novel composites based on either Ca- or Zn-alginate hydrogels and activated charcoal (AC) particles that would, upon contact with physiological fluids, continuously release at least one bioactive agent directly into the wound area. In addition, AC particles served as carriers of other active substances such as povidone iodine (PVP-I), a very powerful antiseptic, which was used as a model substance.
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Funding data
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Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
Grant numbers 451-03-47/2023-01/200135 -
Horizon 2020
Grant numbers 952033
References
https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance
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Osmokrovic A, Jancic I, Jankovic-Castvan I, Petrovic P, Obradovic B. Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings. Hem Ind 2019; 73 (1): 37-46. https://doi.org/10.2298/HEMIND180629003O
Nesvadbova M, Crosera M, Maina G, Filon FL. Povidone iodine skin absorption: an ex-vivo study. Toxicol Lett 2015;235 (3): 155-60. https://doi.org/10.1016/j.toxlet.2015.04.004