Novel alginate/activated-charcoal platform for local treatment of resistant pathogens in wounds Abstract
Article Sidebar
Main Article Content
Abstract
Antibiotic resistance is one of the biggest threats to global health, food security, and development today and new strategies to address this clinical problem are urgently needed. The aim of this work was to produce novel composites based on either Ca- or Zn-alginate hydrogels and activated charcoal (AC) particles that would, upon contact with physiological fluids, continuously release at least one bioactive agent directly into the wound area. In addition, AC particles served as carriers of other active substances such as povidone iodine (PVP-I), a very powerful antiseptic, which was used as a model substance.
Article Details
Section
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors grant to the Publisher the following rights to the manuscript, including any supplemental material, and any parts, extracts or elements thereof:
- the right to reproduce and distribute the Manuscript in printed form, including print-on-demand;
- the right to produce prepublications, reprints, and special editions of the Manuscript;
- the right to translate the Manuscript into other languages;
- the right to reproduce the Manuscript using photomechanical or similar means including, but not limited to photocopy, and the right to distribute these reproductions;
- the right to reproduce and distribute the Manuscript electronically or optically on any and all data carriers or storage media – especially in machine readable/digitalized form on data carriers such as hard drive, CD-Rom, DVD, Blu-ray Disc (BD), Mini-Disk, data tape – and the right to reproduce and distribute the Article via these data carriers;
- the right to store the Manuscript in databases, including online databases, and the right of transmission of the Manuscript in all technical systems and modes;
- the right to make the Manuscript available to the public or to closed user groups on individual demand, for use on monitors or other readers (including e-books), and in printable form for the user, either via the internet, other online services, or via internal or external networks.
How to Cite
Funding data
-
Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
Grant numbers 451-03-47/2023-01/200135 -
Horizon 2020
Grant numbers 952033
References
https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance
Osmokrovic A, Jancic I, Vunduk J, Petrovic P, Milenkovic M, Obradovic B. Achieving high antimicrobial activity: composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent. Carb Pol 2018; 196: 279-88. https://doi.org/10.1016/j.carbpol.2018.05.045
Osmokrovic A, Jancic I, Jankovic-Castvan I, Petrovic P, Obradovic B. Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings. Hem Ind 2019; 73 (1): 37-46. https://doi.org/10.2298/HEMIND180629003O
Nesvadbova M, Crosera M, Maina G, Filon FL. Povidone iodine skin absorption: an ex-vivo study. Toxicol Lett 2015;235 (3): 155-60. https://doi.org/10.1016/j.toxlet.2015.04.004