Sr/Mg – doped bioceramic scaffolds for biomedical application Abstract
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Abstract
Bone is a mineralized connective tissue with remarkable self-healing capability. However, in the presence of large bone defects (≥ 2.5 cm), bone self-recovery is not efficient, necessitating surgical intervention and the introduction of a bone substitute. Hydroxyapatite (HAP) is a widely investigated material for bone tissue engineering (BTE) due to its similarity to the biological apatite found in bones and teeth. Mesoporous bioactive glasses (MBAGs), quickly bind to surrounding tissues and release ions promoting the formation of new bone. The silica from glass enhances angiogenesis, which is a pivotal consideration given the high vascularization level of this tissue. Ion-doping approach of both HAP and MBAG particles has gained great attention due to the ability of therapeutical ions to stimulate a certain cell response. The project aims to develop and characterize bioceramic scaffolds based on a combination of Sr/Mg-doped HAP and MBAG, thereby promoting osteogenesis and creating a favourable environment for the proliferation of endothelial cells.
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Funding data
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Horizon 2020 Framework Programme
Grant numbers 952033
References
Lalzawmliana, V., Anand, A., Roy, M., Kundu, B., & Nandi, S. K. (2020). Mesoporous bioactive glasses for bone healing and biomolecule delivery. Mater. Sci. Eng. C
Pantulap U, Arango-Ospina M, Boccaccini AR. Bioactive glasses incorporating less-common ions to improve biological and physical properties. J Mater Sci Mater Med. 2021 Dec 23;33(1):3. https://doi.org/10.1007/s10856-021-06626-3