3D printing of composites containing copper-incorporated mesoporous bioactive glass induce different cell responses depending on cell type and donor Abstract
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Bioactive glasses are used for dental and orthopaedic applications thanks to their osteoconductivity and bioactive properties. Mesoporous bioactive glasses (MBG) are special type of bioactive glasses with highly ordered channel structure and high specific surface area, which can be loaded with drugs and growth factors, making them suitable as delivery systems. Besides that, their structure can be modified by substitution with bioactive metal ions assessing desired therapeutic effect after release. With that in mind, ions showing antimicrobial effect would be appropriate solution for prevention and treatment of implant-related infections. However, certain ions such as Cu2+ can be cytotoxic at concentrations effective against bacteria. Ion release from MBG can be tuned and controlled by integrating MBG in established biomaterial inks. Our aim here was to investigate release of Cu2+ from 3D printed composite scaffolds containing MBG and to evaluate effects of release products on human pre-osteoblasts (hOB), primary and immortalized mesenchymal stem cells (hMSC).
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