Evaluation of crosslinked gelatin-polyvinylpyrrolidone scaffold for application in drug delivery and tissue engineering Abstract
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Abstract
The objective of this study was to process and evaluate a suitable scaffold matrix system for drug delivery and tissue regeneration. A bioinspired approach was applied. The scaffold based on natural polymer gelatin, blended with polyvinylpyrrolidone, and crosslinked by genipin, was 3D printed by semi-solid extrusion (SSE). This 3D printing technique does not require high temperature or UV curing, so it allows the use of thermo- and UV-sensitive drugs, cells, or other biological components. The influence of genipin, a natural crosslinking agent, and its content on the mechanical properties and the cytotoxicity of obtained scaffolds were investigated.
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Funding data
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Horizon 2020 Framework Programme
Grant numbers 952033
References
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