Chemotherapy and novel proton radiotherapy in spatially advanced multicellular models of pancreatic cancer: On the design of platform for enabling low cost animal free preclinical treatment testing Abstract
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Abstract
With a 5-year of only 11% pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest diseases. This is partly attributed to the tumour’s resistance to currently available treatment, resulting from a complex and highly heterogeneous tumour microenvironment (TME). A key challenge in cancer tissue engineering is to mimic the different key features of the TME. In this work we have developed robust, PDAC biomimetic models for in vitro therapeutic assessment.
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Medical Research Council
Grant numbers MR/V028553/1
References
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