Unraveling the transcriptome profile of pulsed electromagnetic field stimulation in bone regeneration using an in vitro investigation platform Abstract
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Abstract
Perfusion bioreactors are currently a good tool for applications in regenerative medicine and bone tissue engineering. In the realm of bone and cartilage regeneration, pulsed electromagnetic field (PEMF) stimulation has become widely utilized in clinical practice. Numerous signaling pathways involved in its osteogenic, chondrogenic, and anti-inflammatory effects have been identified, but the majority of the pathways are yet unknown. Using a novel in vitro investigation platform, this study aimed to identify the signaling pathways altered by PEMF by exposing3D bone-like models to physiological-like perfusion and PEMF stimulation.
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