Development of an in vitro branched vasculature using bioprinting technique in combination with sacrificial materials Abstract
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Abstract
Successful vascularization represents a bottleneck in the production of functional, engineered tissue constructs. The current methods of vascularization either rely on cells self-organization into the capillary network, or predesigned, biofabricated vessels that are limited in size and do not allow the replication of complex vascular networks. Proposed strategies for solving this problem include combinations of natural and synthetic hydrogels with different gelation properties, 3D bioprinting and single or multiple cell cultures with endothelial cells. However, producing defined, capillary-sized hollow channels remains to be beyond reach.
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