Optimization of ultrasound-assisted extraction of (poly)phenolic compounds from blueberry (Vaccinium myrtillus) leaves

Original scientific paper

Authors

  • Nebojša Vasiljević 1Faculty of Technology, University of East Sarajevo, Zvornik, Republic of Srpska, B&H and Faculty of Technology, University of Novi Sad, Novi Sad, Serbia https://orcid.org/0000-0002-3789-9975
  • Vladan Mićić Faculty of Technology, University of East Sarajevo, Zvornik, Republic of Srpska, B&H https://orcid.org/0000-0002-4383-4879
  • Mitar Perušić Faculty of Technology, University of East Sarajevo, Zvornik, Republic of Srpska, B&H https://orcid.org/0000-0001-9335-1405
  • Marija Mitrović Faculty of Technology, University of East Sarajevo, Zvornik, Republic of Srpska, B&H https://orcid.org/0000-0002-3208-016X
  • Duško Kostić Faculty of Technology, University of East Sarajevo, Zvornik, Republic of Srpska, B&H

DOI:

https://doi.org/10.2298/CICEQ240207028V

Keywords:

anthocyanins, blueberry, extraction, flavonoids, optimization, (poly)phenols

Abstract

The present paper aims to discover the optimal conditions for ultrasound-assisted extraction (UAE) of (poly)phenolic chemicals from blueberry (Vaccinium Myrtillus) leaves. UAE was performed under the following process conditions: temperature: 25 - 65 °C, ethanol concentration in the extraction solvent: 30 – 90 vol.%, and solid-to-solvent ratio: 1:15 - 1:45 w/v. Statistical analysis was performed using Design-Expert software, using the Box-Behnken design. The study's Responses were the content of total (poly)phenols, flavonoids, and anthocyanins in the derived extracts. The results indicated that the corresponding response surface models were highly statistically significant (p < 0.0001) and sufficient to describe and predict the content of total (poly)phenols, the content of flavonoids and the content of anthocyanins with R2 of 0.9653, 0.9796 and 0.9720, respectively. The optimal conditions for the extraction are: for total (poly)phenols, 48.4°C, 51.3 vol.% ethanol, and 1:43.8 w/v solid-to-solvent ratio; for flavonoids, 58.5°C, 48.0 vol.% ethanol, and 1:29.8 w/v ratio; and for anthocyanins, 64.2°C, 73.5 vol.% ethanol, and 1:44.7 w/v ratio. The use of UAE enhances extraction yields by increasing the release of bioactive compounds, while the application of the Box-Behnken design allows for precise determination of optimal extraction parameters, thereby achieving maximum yields and efficiency.

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Copyright (c) 2023 Nebojša Vasiljević, Vladan Mićić, Mitar Perušić, Marija Mitrović, Duško Kostić

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How to Cite

Optimization of ultrasound-assisted extraction of (poly)phenolic compounds from blueberry (Vaccinium myrtillus) leaves: Original scientific paper. (2024). Chemical Industry & Chemical Engineering Quarterly. https://doi.org/10.2298/CICEQ240207028V

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